Smith & Nephew SNATS, Inc. Common Stock (SNN)

Smith+Nephew (LSE:SN, NYSE:SNN), the global medical technology company, today announces it received 510(k) clearance from the U.S. Food and Drug Administration (FDA) and has completed the first surgical cases with LANDMARK Total Knee System, a next-generation knee replacement solution designed to replicate healthy knee anatomy and the knee’s natural motion and support a more personalized approach to total knee arthroplasty.As expectations for total knee arthroplasty continue to evolve, surgeons and patients are seeking the most advanced and tailored solutions when they choose a knee replacement solution. The LANDMARK Knee meets those goals through an anatomy-driven implant that was designed to leverage the full capabilities of CORI◊ KNEE Handheld Robotics Arthroplasty.1 The compact footprint and mobility of Handheld Robotics is optimized for use across both hospital and ambulatory surgery center (ASC) environments.Key features of the LANDMARK Knee include:     • Designed to replicate healthy knee anatomy and restore the natural motion and A/P position with less compromise2-6*     • Smooth, flat trochlear groove entry point to promote more natural patella tracking 2,7,8*     • Fully 3D-printed femoral component utilizing CONCELOC◊ Technology3“It is truly a landmark moment for Orthopaedics at Smith+Nephew. The future of knee replacement is increasingly personalized, and surgeons need technologies that help them deliver individualized care with confidence and efficiency,” said Nate Folkert, President, Smith+Nephew Orthopaedics. “Together, the natural design of LANDMARK Knee paired with CORI KNEE Handheld Robotics Arthroplasty provides a powerful solution to address the evolving needs of orthopaedic surgery."The first LANDMARK Knee surgical cases were completed this week by Dr. Steven MacDonald, Professor of Orthopaedic Surgery, Western University and London Health Sciences Centre in London, Ontario, who is one of the surgeons who helped with the design and development of this innovative implant system. “Knee replacement surgery has changed so much in recent years driven by the momentum of personalized medicine and an influx of innovative approaches,” explained Dr. MacDonald. “Whether achieved via the state-of-the-art new LANDMARK instrumentation system or in combination with the planning and balancing capabilities of the CORI KNEE Handheld Robotics Arthroplasty, the LANDMARK Knee provides us the flexibility to make patient-specific decisions while maintaining procedural efficiency. It is the perfect fit for surgeons looking to align with the principles of personalized care as the LANDMARK Knee was designed to meet the needs of surgeons and patients today and tomorrow.” Dr. Steven Haas, Chief of the Knee Service at Hospital for Special Surgery (HSS) in New York, was also a surgeon developer for the LANDMARK Knee. "The LANDMARK Knee was designed to address one of the biggest challenges in total knee arthroplasty, which is restoring anatomy without forcing unnecessary compromise," Dr. Haas said. "Its anatomic design helps accommodate the patient's natural anatomy while supporting personalized alignment and patellofemoral function.”The LANDMARK Knee will be commercially introduced through a phased launch focused on early customer adoption, with broader availability across markets expected throughout 2027. Smith+Nephew will be unveiling its new knee system to HCP attendees during the American Association of Hip & Knee Surgeons (AAHKS) Annual Meeting in Dallas November 5-8. Stop by booth number 621 to see the new LANDMARK Knee in action.To learn more, visit our LANDMARK Knee web page.                                                                                                       - ends -  Media InquiriesGina Kamler+1 (901) 262-9070gina.kamler@smith-nephew.com*Compared to conventional TKA designsReferences 1. Smith+Nephew 2026. Internal Report. CSD.REC.26.003_v12. Smith + Nephew 2026. Internal Report. CSD.REC.26.004_v13. Smith+Nephew 2026. Internal Report. K24-PFET/CFET4. Grieco TF, Sharma A, Dessinger GM, Cates HE, Komistek RD. In Vivo Kinematic Comparison of a Bicruciate Stabilized Total Knee Arthroplasty and the Normal Knee Using Fluoroscopy. J Arthroplasty. 2018;33(2):565-571.5. Almaawi A, Hutt J, Masse V, Lavigne M, Vendittoli P. Impact of mechanical and restricted kinematic alignment on Knee anatomy in Total Knee Arthroplasty. J Arthroplasty. 2017;32(7):2133-2140.6. MacDessi SJ, Griffith-Jones W, Harris IA, Bellemans J, Chen DB. Coronal Plane Alignment of the Knee (CPAK) classification. Bone Joint J. 2021;103-B(2):329-337. 7. Smith+Nephew 2026. Verification for Femur Implants7. Fugit W, Lenz N. “Challenging Native Patella Positions Benefit with Flat Proximal Trochlea” The International Society for Technology in Arthroplasty, 37th Annual Congress, 2026, Munich, Germany, September8. Fugit W, Lenz N. "The Benefits of a Kinematically Designed Femoral Implant Versus Symmetric Implants” The International Society for Technology in Arthroplasty, 37th Annual Congress, 2026, Munich, Germany, SeptemberAbout Smith+NephewSmith+Nephew is a portfolio medical technology business focused on the repair, regeneration and replacement of soft and hard tissue. We exist to restore people’s bodies and their self-belief by using technology to take the limits off living. We call this purpose ‘Life Unlimited’. Our 17,000 employees deliver this mission every day, making a difference to patients’ lives through the excellence of our product portfolio, and the invention and application of new technologies across our three global business units of Orthopaedics, Sports Medicine & ENT and Advanced Wound Management.Founded in Hull, UK, in 1856, we now operate in around 100 countries, and generated annual sales of $6.2 billion in 2025. Smith+Nephew is a constituent of the FTSE100 (LSE:SN, NYSE:SNN). The terms ‘Group’ and ‘Smith+Nephew’ are used to refer to Smith & Nephew plc and its consolidated subsidiaries, unless the context requires otherwise.For more information about Smith+Nephew, please visit www.smith-nephew.com and follow us on X, LinkedIn, Instagram or Facebook.Forward-looking StatementsThis document may contain forward-looking statements that may or may not prove accurate. For example, statements regarding expected revenue growth and trading profit margins, market trends and our product pipeline are forward-looking statements. Phrases such as "aim", "plan", "intend", "anticipate", "well-placed", "believe", "estimate", "expect", "target", "consider" and similar expressions are generally intended to identify forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and other important factors that could cause actual results to differ materially from what is expressed or implied by the statements. For Smith+Nephew, these factors include: conflicts in Europe and the Middle East, economic and financial conditions in the markets we serve, especially those affecting healthcare providers, payers and customers; price levels for established and innovative medical devices; developments in medical technology; regulatory approvals, reimbursement decisions or other government actions; product defects or recalls or other problems with quality management systems or failure to comply with related regulations; litigation relating to patent or other claims; legal and financial compliance risks and related investigative, remedial or enforcement actions; disruption to our supply chain or operations or those of our suppliers; competition for qualified personnel; strategic actions, including acquisitions and disposals, our success in performing due diligence, valuing and integrating acquired businesses; disruption that may result from transactions or other changes we make in our business plans or organisation to adapt to market developments; relationships with healthcare professionals; reliance on information technology and cybersecurity; disruptions due to natural disasters, weather and climate change related events; changes in customer and other stakeholder sustainability expectations; changes in taxation regulations; effects of foreign exchange volatility; and numerous other matters that affect us or our markets, including those of a political, economic, business, competitive or reputational nature. Please refer to the documents that Smith+Nephew has filed with the U.S. Securities and Exchange Commission under the U.S. Securities Exchange Act of 1934, as amended, including Smith+Nephew's most recent annual report on Form 20-F, which is available on the SEC’s website at www. sec.gov, for a discussion of certain of these factors. Any forward-looking statement is based on information available to Smith+Nephew as of the date of the statement. All written or oral forward-looking statements attributable to Smith+Nephew are qualified by this caution. Smith+Nephew does not undertake any obligation to update or revise any forward-looking statement to reflect any change in circumstances or in Smith+Nephew's expectations.◊ Trademark of Smith+Nephew. Certain marks registered in US Patent and Trademark Office.

Smith+Nephew (LSE:SN, NYSE:SNN), the global medical technology company, today announces it will highlight a suite of advanced solutions for shoulder repair and reconstruction at the International Congress for Shoulder and Elbow Surgery (ICSES) in Vancouver from September 22-25. Surgeons are invited to visit the Smith+Nephew booth during ICSES to learn more about the following technologies:

Smith+Nephew announces results of its cash tender offer for up to $250 million of its outstanding 2.032% notes due 2030

Smith+Nephew announces pricing of its cash tender offer for up to $250 million of its outstanding 2.032% notes due 2030

Smith+Nephew announces cash tender offer for up to $250 million of its outstanding 2.032% notes due 2030

Marking a new approach to innovation in medical robotics, the new centre will bring advances from a leading surgical robotics research group to patients more quickly

Smith+Nephew (LSE:SN, NYSE:SNN), the global medical technology company, today announces a breakthrough in RF resection technology for hip with its new FLOW FLEXTEND COBLATION Wand. Designed as an extension of its proprietary FLOW~IQ◊ technology with an adjustable-angle tip, the FLOW FLEXTEND Wand is designed to give surgeons enhanced joint access1* and precise tissue targeting3 for hard-to-reach hip, knee and shoulder anatomies.

Smith & Nephew SNATS (NYSE:SNN) reported second-quarter underlying revenue growth of 1.6%, below management’s expectations, as continued strength in Sports Medicine and ENT was offset by weakness in U.S. Orthopaedics and Advanced Wound Bioactives. Chief Executive Officer Deepak Nath said quarte

Canton, Ohio—As thousands of football fans descend on Canton for the 2026 Pro Football Hall of Fame Enshrinement Week, Smith+Nephew, the Global medical technology company, will join the celebration with a series of engagement activities highlighting the connection between movement, recovery and the enduring spirit of the game. Smith+Nephew is the official Joint Replacement and Sports Medicine Technology Partner of the Pro Football Hall of Fame.

Nath addresses Orthopaedics gaps and skin substitute headwinds.

Smith+Nephew (LSE:SN, NYSE:SNN), the global medical technology company, today announces it has been granted De Novo classification by the U.S. Food & Drug Administration (FDA) for its TESSA Spatial Surgery System. Utilizing cutting-edge accelerated computing and AI technology, the TESSA (Tracking Enabled Spatial Surgery Assistant) System brings personalized planning, augmented reality, advanced imaging, navigation, and real-time tracking to help transform arthroscopic procedures, leveraging technology originally developed by Perceive3D S.A., a spin-off from the University of Coimbra that became part of Smith+Nephew through acquisition.

Smith+Nephew (LSE: SN, NYSE: SNN), the global medical technology company, today announced ASC Solutions: an expanded enterprise strategy for ambulatory surgery centers (ASCs) that takes a customer-centric approach to helping ASC customers realise their key objectives of cost optimization, quality, and outcome performance.

Delivering versatility for airway procedures in a single, streamlined surgical solution

Issued on behalf of Conexeu Sciences Inc.

Smith+Nephew (LSE:SN, NYSE:SNN), the global medical technology company, announces the US launch of next generation LEAF♢ Patient Monitoring System, a data-driven pressure injury prevention platform designed to help health care providers tackle the growing burden of hospital-acquired pressure injuries (HAPIs) by strengthening protocols and outcomes. The LEAF System uses a wearable sensor to monitor patient mobility and provide real-time turn status updates, helping to improve workflow efficiency, turn quality, and protocol adherence.1-3

Issued on behalf of Conexeu Sciences Inc.

Smith+Nephew (LSE:SN, NYSE:SNN), the global medical technology company, continues to drive progress in chronic wound management with an industry-leading portfolio set to showcase at the upcoming European Wound Management Association (EWMA) Conference, Bremen between 6-8 May 2026.

Smith+Nephew (LSE:SN, NYSE:SNN), the global medical technology company, today announces further compelling evidence from a multicenter, randomized controlled trial highlighting the clinical superiority of its CARTIHEAL AGILI-C Cartilage Repair Implant recently published in the American Journal of Sports Medicine (AJSM). The CARTIHEAL AGILI-C Cartilage Repair Implant resulted in higher overall Knee injury and Osteoarthritis Outcome Scores (KOOS) versus surgical standard of care* for all time points out to 60 months.1,2

Results from the first-ever randomized control trial for the REGENETEN Implant in partial-thickness rotator cuff repair

Smith+Nephew (LSE:SN, NYSE:SNN), the global medical technology company, recently announced the launch of ALLEVYN♢ COMPLETE CARE Foam Dressing, featuring proprietary technologies and performance backed by a portfolio of strong scientific data and clinical evidence.